MEF2C

MEF2C
Factor potenciador específico de miocito 2C
Protein MEF2C PDB 1c7u.png
Estructura tridimensional de la proteína MEF2C.
HUGO 6996
Símbolo MEF2C
Datos genéticos
Locus Cr. 5 q14.3
Bases de datos
Entrez 4208
OMIM 600662
PDB 1c7u
RefSeq NP_002388
UniProt Q06413

El factor potenciador específico de miocito 2C (MEF2C, de sus siglas en inglés "Myocyte-specific enhancer factor 2C") es una proteína codificada en humanos por el gen mef2C. MEF2C es un factor de transcripción de la familia Mef2.[1] [2] Esta proteína es necesaria para el correcto desarrollo embrionario: ratones knockout que no poseen una copia funcional del gen mef2C mueren antes de nacer y tienen anomalías en el corazón y en el sistema vascular.[3]

Contenido

Interacciones

El factor potenciador específico de miocito 2A ha demostrado ser capaz de interaccionar con:

Véase también

  • MEF2

Referencias

  1. Molkentin JD, Black BL, Martin JF, Olson EN (1996). «Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.». Mol Cell Biol. 16 (6):  pp. 2627–36. PMID 8649370. 
  2. «Entrez Gene: MEF2C myocyte enhancer factor 2C».
  3. Bi W, Drake CJ, Schwarz JJ (1999). «The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF». Developmental Biology 211 (2):  pp. 255–67. doi:10.1006/dbio.1999.9307. PMID 10395786. 
  4. Yang, C C; Ornatsky O I, McDermott J C, Cruz T F, Prody C A (Oct. 1998). «Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1». Nucleic Acids Res. (ENGLAND) 26 (20):  pp. 4771–7. ISSN 0305-1048. PMID 9753748. 
  5. Sartorelli, V; Huang J, Hamamori Y, Kedes L (Feb. 1997). «Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C». Mol. Cell. Biol. (UNITED STATES) 17 (2):  pp. 1010–26. ISSN 0270-7306. PMID 9001254. 
  6. Krainc, D; Bai G, Okamoto S, Carles M, Kusiak J W, Brent R N, Lipton S A (Oct. 1998). «Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1». J. Biol. Chem. (UNITED STATES) 273 (40):  pp. 26218–24. ISSN 0021-9258. PMID 9748305. 
  7. Maeda, Tomoji; Gupta Mahesh P, Stewart Alexandre F R (Jun. 2002). «TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters». Biochem. Biophys. Res. Commun. (United States) 294 (4):  pp. 791–7. doi:10.1016/S0006-291X(02)00556-9. ISSN 0006-291X. PMID 12061776. 
  8. Hosking, B M; Wang S C, Chen S L, Penning S, Koopman P, Muscat G E (Sep. 2001). «SOX18 directly interacts with MEF2C in endothelial cells». Biochem. Biophys. Res. Commun. (United States) 287 (2):  pp. 493–500. doi:10.1006/bbrc.2001.5589. ISSN 0006-291X. PMID 11554755. 
  9. Wang, A H; Bertos N R, Vezmar M, Pelletier N, Crosato M, Heng H H, Th'ng J, Han J, Yang X J (Nov. 1999). «HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor». Mol. Cell. Biol. (UNITED STATES) 19 (11):  pp. 7816–27. ISSN 0270-7306. PMID 10523670. 
  10. Wang, A H; Yang X J (Sep. 2001). «Histone deacetylase 4 possesses intrinsic nuclear import and export signals». Mol. Cell. Biol. (United States) 21 (17):  pp. 5992–6005. ISSN 0270-7306. PMID 11486037. 

Enlaces externos


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