MEF2D

Factor potenciador específico de miocito 2D
Estructura tridimensional de la proteína MEF2D.
HUGO	6997
Símbolo	MEF2D
Símbolos alt.	DKFZp686I1536
Datos genéticos
Locus	Cr. 1 q22
Bases de datos
Entrez	4209
OMIM	600663
PDB	1c7u
RefSeq	NP_005911
UniProt	Q14814

La factor potenciador específico de miocito 2D (MEF2D) es una proteína codificada en humanos por el gen mef2D.^{[1] [2]}

Interacciones

La proteína MEF2D ha demostrado ser capaz de interaccionar con:

• YWHAQ^[3]
• MAPK7^[4]
• EP300^{[5] [6]}
• Sp1^[7]
• MEF2A^[8]
• NFATC2^[9]
• CABIN1^{[6] [10]}

Véase también

• Mef2

Referencias

1. ↑ Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Feb 1994). «A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage». Development 118 (4):  pp. 1095–106. PMID 8269842. 
2. ↑ «Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)».
3. ↑ Choi, S J; Park S Y, Han T H (Jul. 2001). «14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation». Nucleic Acids Res. (England) 29 (13):  pp. 2836–42. PMID 11433030. 
4. ↑ Yang, C C; Ornatsky O I, McDermott J C, Cruz T F, Prody C A (Oct. 1998). «Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1». Nucleic Acids Res. (ENGLAND) 26 (20):  pp. 4771–7. ISSN 0305-1048. PMID 9753748. 
5. ↑ Youn, H D; Grozinger C M, Liu J O (Jul. 2000). «Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4». J. Biol. Chem. (UNITED STATES) 275 (29):  pp. 22563–7. doi:10.1074/jbc.C000304200. ISSN 0021-9258. PMID 10825153. 
6. ↑ ^{a b} Youn, H D; Liu J O (Jul. 2000). «Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2». Immunity (UNITED STATES) 13 (1):  pp. 85–94. ISSN 1074-7613. PMID 10933397. 
7. ↑ Park, So-Youn; Shin Hyun-Mu, Han Tae-Hee (Sep. 2002). «Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter». Mol. Immunol. (England) 39 (1-2):  pp. 25–30. ISSN 0161-5890. PMID 12213324. 
8. ↑ Ornatsky, O I; McDermott J C (Oct. 1996). «MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells». J. Biol. Chem. (UNITED STATES) 271 (40):  pp. 24927–33. ISSN 0021-9258. PMID 8798771. 
9. ↑ Youn, H D; Chatila T A, Liu J O (Aug. 2000). «Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis». EMBO J. (ENGLAND) 19 (16):  pp. 4323–31. doi:10.1093/emboj/19.16.4323. ISSN 0261-4189. PMID 10944115. 
10. ↑ Youn, H D; Sun L, Prywes R, Liu J O (Oct. 1999). «Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2». Science (UNITED STATES) 286 (5440):  pp. 790–3. ISSN 0036-8075. PMID 10531067. 

Enlaces externos

• MeSH MEF2D+protein,+human