PIK3R3

Subunidad reguladora gamma de la fosfatidilinositol 3-quinasa
Estructura tridimensional de la proteína PIK3R3.
HUGO	8981
Símbolo	PIK3R3
Símbolos alt.	DKFZp686P05226; FLJ41892; p55-GAMMA
Datos genéticos
Locus	Cr. 1 p34.1
Bases de datos
Entrez	8503
OMIM	606076
PDB	2pna
RefSeq	NP_003620
UniProt	Q92569

La subunidad reguladora gamma de la fosfatidilinositol 3-quinasa (PIK3R3) es una enzima codificada en humanos por el gen PIK3R3.^{[1] [2]}

Interacciones

La proteína PIK3R3 ha demostrado ser capaz de interaccionar con:

• IGF1R^[3]
• IRS1^{[4] [3]}
• Proteína del retinoblastoma^[5]

Referencias

1. ↑ Dey BR, Furlanetto RW, Nissley SP (May 1998). «Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor». Gene 209 (1-2):  pp. 175–83. PMID 9524259. 
2. ↑ «Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)».
3. ↑ ^{a b} Mothe, I; Delahaye L, Filloux C, Pons S, White M F, Van Obberghen E (Dec. 1997). «Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins». Mol. Endocrinol. (UNITED STATES) 11 (13):  pp. 1911–23. ISSN 0888-8809. PMID 9415396. 
4. ↑ Xia, X; Serrero G (Aug. 1999). «Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation». Biochem. J. (ENGLAND) 341 ( Pt 3):  pp. 831–7. ISSN 0264-6021. PMID 10417350. 
5. ↑ Xia, Xianmin; Cheng Aiwu, Akinmade Damilola, Hamburger Anne W (Mar. 2003). «The N-terminal 24 amino acids of the p55 gamma regulatory subunit of phosphoinositide 3-kinase binds Rb and induces cell cycle arrest». Mol. Cell. Biol. (United States) 23 (5):  pp. 1717–25. ISSN 0270-7306. PMID 12588990.