PRKG1

Proteína quinasa dependiente del cGMP tipo I
HUGO	9414
Símbolo	cGK1
Datos genéticos
Código de gen	PRKG1
Tipo de gen	Gen codificante
Locus	Cr. 10 q11.2
Estructura/Función proteica
Tamaño	671 (aminoácidos)
Bases de datos
Número EC	2.7.11.12
Entrez	5592
OMIM	176894
RefSeq	NM_001098512
UniProt	Q13976

La proteína quinasa GMPc dependiente tipo I (PRKG1) (EC 2.7.11.12) es una enzima codificada en humanos por el gen PRKG1.^{[1] [2] [3]} Pertenece a la familia de las serina/treonina proteína quinasas específicas.

Interacciones

La proteína PRKG1 ha demostrado ser capaz de interaccionar con:

• ITPR1^[4]
• RGS2^[5]
• TNNT1^[6]
• MRVI1^{[4] [7]}
• GTF2I^[8]

Referencias

1. ↑ Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Nov 1989). «Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat». FEBS Lett 255 (2):  pp. 321–9. PMID 2792381. 
2. ↑ Orstavik S, Sandberg M, Berube D, Natarajan V, Simard J, Walter U, Gagne R, Hansson V, Jahnsen T (Apr 1992). «Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10». Cytogenet Cell Genet 59 (4):  pp. 270–3. PMID 1544322. 
3. ↑ «Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I».
4. ↑ ^{a b} Schlossmann, J; Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang G X, Allescher H D, Korth M, Wilm M, Hofmann F, Ruth P (Mar. 2000). «Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta». Nature (ENGLAND) 404 (6774):  pp. 197–201. doi:10.1038/35004606. ISSN 0028-0836. PMID 10724174. 
5. ↑ Tang, K Mary; Wang Guang-rong, Lu Ping, Karas Richard H, Aronovitz Mark, Heximer Scott P, Kaltenbronn Kevin M, Blumer Kendall J, Siderovski David P, Zhu Yan, Mendelsohn Michael E, Tang Mary, Wang Guang (Dec. 2003). «Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure». Nat. Med. (United States) 9 (12):  pp. 1506–12. doi:10.1038/nm958. ISSN 1078-8956. PMID 14608379. 
6. ↑ Yuasa, K; Michibata H, Omori K, Yanaka N (Dec. 1999). «A novel interaction of cGMP-dependent protein kinase I with troponin T». J. Biol. Chem. (UNITED STATES) 274 (52):  pp. 37429–34. ISSN 0021-9258. PMID 10601315. 
7. ↑ Ammendola, A; Geiselhöringer A, Hofmann F, Schlossmann J (Jun. 2001). «Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta». J. Biol. Chem. (United States) 276 (26):  pp. 24153–9. doi:10.1074/jbc.M101530200. ISSN 0021-9258. PMID 11309393. 
8. ↑ Casteel, Darren E; Zhuang Shunhui, Gudi Tanima, Tang Julian, Vuica Milena, Desiderio Stephen, Pilz Renate B (Aug. 2002). «cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I». J. Biol. Chem. (United States) 277 (35):  pp. 32003–14. doi:10.1074/jbc.M112332200. ISSN 0021-9258. PMID 12082086.