YY1

Represor transcripcional YY1
Estructura tridimensional de la proteína YY1.
HUGO	12856
Símbolo	YY1
Símbolos alt.	DELTA; NF-E1; UCRBP; YIN-YANG-1
Datos genéticos
Locus	Cr. 14 q32.2
Bases de datos
Entrez	7528
OMIM	600013
PDB	1ubd
RefSeq	NP_003394
UniProt	P25490

El represor transcripcional YY1 (YY1) es una proteína codificada en humanos por el gen YY1.^{[1] [2]}

YY1 es un factor de transcripción distribuido ubícuamente, perteneciente a la clase GLI-Kruppel de proteínas con dedos de zinc. Es una proteína implicada en la represión y activación de diversos promotores. YY1 puede dirigir las histona deacetilasas y las histona acetiltransferasas hacia los promotores, además de activar o reprimir el promotor en cuestión, por lo que presenta un papel relevante en la modificación de histonas.^[3]

Interacciones

La proteína YY1 ha demostrado ser capaz de interaccionar con:

• HDAC2^{[4] [5] [6]}
• FKBP3^[7]
• ATF6^[8]
• Myc^[9]
• SAP30^[10]
• EP300^{[5] [11]}
• HDAC3^{[4] [5]}
• Notch1^[12]
• RYBP^[13]

Referencias

1. ↑ Shi Y, Seto E, Chang LS, Shenk T (Nov 1991). «Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein». Cell 67 (2):  pp. 377–88. PMID 1655281. 
2. ↑ Zhu W, Lossie AC, Camper SA, Gumucio DL (Jul 1994). «Chromosomal localization of the transcription factor YY1 in the mouse and human». Mamm Genome 5 (4):  pp. 234–6. PMID 7912122. 
3. ↑ «Entrez Gene: YY1 YY1 transcription factor».
4. ↑ ^{a b} Yang, W M; Yao Y L, Sun J M, Davie J R, Seto E (Oct. 1997). «Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family». J. Biol. Chem. (UNITED STATES) 272 (44):  pp. 28001–7. ISSN 0021-9258. PMID 9346952. 
5. ↑ ^{a b c} Yao, Y L; Yang W M, Seto E (Sep. 2001). «Regulation of transcription factor YY1 by acetylation and deacetylation». Mol. Cell. Biol. (United States) 21 (17):  pp. 5979–91. ISSN 0270-7306. PMID 11486036. 
6. ↑ Kalenik, J L; Chen D, Bradley M E, Chen S J, Lee T C (Feb. 1997). «Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1». Nucleic Acids Res. (ENGLAND) 25 (4):  pp. 843–9. ISSN 0305-1048. PMID 9016636. 
7. ↑ Yang, W M; Yao Y L, Seto E (Sep. 2001). «The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1». EMBO J. (England) 20 (17):  pp. 4814–25. doi:10.1093/emboj/20.17.4814. ISSN 0261-4189. PMID 11532945. 
8. ↑ Li, M; Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee A S (Jul. 2000). «ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1». Mol. Cell. Biol. (UNITED STATES) 20 (14):  pp. 5096–106. ISSN 0270-7306. PMID 10866666. 
9. ↑ Shrivastava, A; Saleque S, Kalpana G V, Artandi S, Goff S P, Calame K (Dec. 1993). «Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc». Science (UNITED STATES) 262 (5141):  pp. 1889–92. ISSN 0036-8075. PMID 8266081. 
10. ↑ Huang, Nu En; Lin Ching Hui, Lin Young Sun, Yu Winston C Y (Jun. 2003). «Modulation of YY1 activity by SAP30». Biochem. Biophys. Res. Commun. (United States) 306 (1):  pp. 267–75. ISSN 0006-291X. PMID 12788099. 
11. ↑ Lee, J S; Galvin K M, See R H, Eckner R, Livingston D, Moran E, Shi Y (May. 1995). «Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300». Genes Dev. (UNITED STATES) 9 (10):  pp. 1188–98. ISSN 0890-9369. PMID 7758944. 
12. ↑ Yeh, Tien-Shun; Lin Yu-Min, Hsieh Rong-Hong, Tseng Min-Jen (Oct. 2003). «Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch». J. Biol. Chem. (United States) 278 (43):  pp. 41963–9. doi:10.1074/jbc.M304353200. ISSN 0021-9258. PMID 12913000. 
13. ↑ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (Jun. 1999). «RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1». EMBO J. (ENGLAND) 18 (12):  pp. 3404–18. doi:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMID 10369680.