NOD2


NOD2
nucleotide-binding oligomerization domain containing 2
240
Esquema del gen NOD2 CARD15, asociado con ciertos patrones de la enfermedad de Chron
HUGO 5331
Símbolo NOD2
Símbolos alt. IBD1, CARD15, CLR16.3, NLRC2
Datos genéticos
Locus Cr. 4 q21
Bases de datos
Entrez 64127
OMIM 605956
RefSeq NM_022162
UniProt Q9HC29

NOD2 (por sus siglas en inglés, nucleotide-binding oligomerization domain containing 2) es una proteína, también conocida como dominio reclutador de caspasa 15 (CARD15), que desempeña un importante papel en el sistema inmune. Se trata de un receptor de reconocimiento de patrones, que es similar en estructuraa proteínas resistentes de plantas y reconoce moléculas que contienen una estructura específica llamada muramil dipéptido (MDP), que se encuentra en ciertas bacterias.[1]

El gen que codifica para NOD2 está relacionado con enfermedades inflamatorias como la enfermedad de Chron.[2] [3] El gen de NOD2 se encuentra localizado en el cromosoma 16 en humanos.

Referencias

  1. Kufer T, Banks D, Philpott D (2006). «Innate immune sensing of microbes by Nod proteins». Ann. N. Y. Acad. Sci. 1072:  pp. 19-27. PMID 17057187. 
  2. Radford-Smith G, Pandeya N (2006). «Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?». World J. Gastroenterol. 12 (44):  pp. 7097-103. PMID 17131470. 
  3. Kim T, Payne U, Zhang X, Iwanaga Y, Davey M, Rosenbaum J, Inman R (2007). «Altered host:pathogen interactions conferred by the Blau syndrome mutation of NOD2». Rheumatol. Int. 27 (3):  pp. 257-62. PMID 17096091. 

Enlaces externos

http://www.genecards.org/cgi-bin/carddisp.pl?gene=CARD15&search=nod2


Wikimedia foundation. 2010.

Mira otros diccionarios:

  • NOD2 — Обозначения Символы NOD2; BLAU, CD, CLR16.3, NLRC2, PSORAS1, CARD15, IBD1 Entrez Gene …   Википедия

  • NOD2 — Nucleotide binding oligomerization domain containing 2 Identifiers Symbols NOD2; ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1 External IDs …   Wikipedia

  • Болезнь Крона — Специфическая гранулёма в стенке толстой кишки. Хорошо видны гигантские, многоядерные клетки типа Пирогова Лангхан …   Википедия

  • Crohn's disease — Classification and external resources The three most common sites of intestinal involvement in Crohn s disease are ileal, ileocolic and colonic.[ …   Wikipedia

  • Population groups in biomedicine — Biomedical researchers subdivide populations into groups with the goal of improving the prevention and treatment of diseases. Many studies have found that disease susceptibility and environmental responses vary among U.S. ethnicities, among New… …   Wikipedia

  • Race and health — research is mostly from the United States. It has found both current and historical racial differences in the frequency, treatments, and availability of treatments for several diseases. This can add up to significant group differences in… …   Wikipedia

  • NOD1 — Nucleotide binding oligomerization domain containing 1 PDB rendering based on 2b1w …   Wikipedia

  • Pattern recognition receptor — Pattern recognition receptors (PRRs) are a primitive part of the immune system. They are proteins expressed by cells of the innate immune system to identify pathogen associated molecular patterns (PAMPs), which are associated with microbial… …   Wikipedia

  • NLRC4 — NLR family, CARD domain containing 4 Identifiers Symbols NLRC4; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF External IDs …   Wikipedia

  • Chronische Enteritis — Klassifikation nach ICD 10 K50. Crohn Krankheit [Enteritis regionalis] [Morbus Crohn] K50.0 Crohn Krankheit des Dünndarmes I5642 K50.1 …   Deutsch Wikipedia