NEK2

Serina/treonina quinasa Nek2
Estructura tridimensional de la proteína NEK2.
HUGO	7745
Símbolo	NEK2
Símbolos alt.	HsPK 21, HsPK21, NEK2A, NLK1
Datos genéticos
Locus	Cr. 1 q32.3
Bases de datos
Entrez	4751
OMIM	604043
PDB	2jav
RefSeq	NP_002488
UniProt	P51955

La serina/treonina quinasa Nek2 es una enzima codificada en humanos por el gen nek2.^{[1] [2]}

Interacciones

La proteína NEK2 ha demostrado ser capaz de interaccionar con:

• MAPK1^[3]
• NDC80^{[4] [5]}

Referencias

1. ↑ Schultz SJ, Nigg EA (Feb 1994). «Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans». Cell Growth Differ 4 (10):  pp. 821–30. PMID 8274451. 
2. ↑ «Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2».
3. ↑ Lou, Yang; Xie Wei, Zhang Dong-Fang, Yao Jian-hui, Luo Zhao-feng, Wang Yu-Zhen, Shi Yun-Yu, Yao Xue-Biao (Aug. 2004). «Nek2A specifies the centrosomal localization of Erk2». Biochem. Biophys. Res. Commun. (United States) 321 (2):  pp. 495–501. doi:10.1016/j.bbrc.2004.06.171. ISSN 0006-291X. PMID 15358203. 
4. ↑ Chen, Yumay; Riley Daniel J, Zheng Lei, Chen Phang-Lang, Lee Wen-Hwa (Dec. 2002). «Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation». J. Biol. Chem. (United States) 277 (51):  pp. 49408–16. doi:10.1074/jbc.M207069200. ISSN 0021-9258. PMID 12386167. 
5. ↑ Chen, Y; Sharp Z D, Lee W H (Sep. 1997). «HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins». J. Biol. Chem. (UNITED STATES) 272 (38):  pp. 24081–7. ISSN 0021-9258. PMID 9295362.