PEA15

Fosfoproteína astrocítica 15
Estructura tridimensional de la proteína PEA15.
HUGO	8822
Símbolo	PEA15
Símbolos alt.	MAT1, PED, HMAT1, HUMMAT1H, MAT1H, PEA-15
Datos genéticos
Locus	Cr. 1 q23.2
Bases de datos
Entrez	8682
OMIM	603434
PDB	1n3k
RefSeq	NP_003759
UniProt	Q15121

La fosfoproteína astrocítica 15 (PEA15) es una proteína codificada en humanos por el gen pea15.^{[1] [2]}

La proteína PEA15 contiene un dominio efector de muerte (DED) y se expresa de forma predominante en el sistema nervioso central, particularmente en astrocitos.^[2]

Interacciones

La proteína PEA15 ha demostrado ser capaz de interaccionar con:

• Fosfolipasa D1^[3]
• Caspasa 8^{[4] [5]}
• MAPK1^[6]
• FADD^{[4] [5]}
• RPS6KA3^[7]

Referencias

1. ↑ Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay G, Myambo K, Collins CC (Sep 1997). «Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers». Genomics 42 (3):  pp. 540–2. PMID 9205133. 
2. ↑ ^{a b} «Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15».
3. ↑ Zhang, Y; Redina O, Altshuller Y M, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman M A (Nov. 2000). «Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them». J. Biol. Chem. (UNITED STATES) 275 (45):  pp. 35224–32. doi:10.1074/jbc.M003329200. ISSN 0021-9258. PMID 10926929. 
4. ↑ ^{a b} Kitsberg, D; Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H (Oct. 1999). «Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis». J. Neurosci. (UNITED STATES) 19 (19):  pp. 8244–51. PMID 10493725. 
5. ↑ ^{a b} Condorelli, G; Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F (Aug. 1999). «PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis». Oncogene (ENGLAND) 18 (31):  pp. 4409–15. doi:10.1038/sj.onc.1202831. ISSN 0950-9232. PMID 10442631. 
6. ↑ Formstecher, E; Ramos J W, Fauquet M, Calderwood D A, Hsieh J C, Canton B, Nguyen X T, Barnier J V, Camonis J, Ginsberg M H, Chneiweiss H (Aug. 2001). «PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase». Dev. Cell (United States) 1 (2):  pp. 239–50. ISSN 1534-5807. PMID 11702783. 
7. ↑ Vaidyanathan, Hema; Ramos Joe W (Aug. 2003). «RSK2 activity is regulated by its interaction with PEA-15». J. Biol. Chem. (United States) 278 (34):  pp. 32367–72. doi:10.1074/jbc.M303988200. ISSN 0021-9258. PMID 12796492.