TLE1

Transducin-like enhancer of split 1
Estructura tridimensional de la proteína TLE1.
HUGO	11837
Símbolo	TLE1
Símbolos alt.	ESG, ESG1, GRG1
Datos genéticos
Locus	Cr. 9 qq21.31-q21.32
Bases de datos
Entrez	7088
OMIM	600189
PDB	1gxr
RefSeq	NP_005068
UniProt	Q04724

La proteína TLE1 (de sus siglas en inglés "Transducin-like enhancer protein 1") es un factor de transcripción codificado en humanos por el gen tle1.^{[1] [2] [3]}

Interacciones

La proteína TLE1 ha demostrado ser capaz de interaccionar con:

• TLE2^[4]
• Glicoproteína 130^[5]
• UTY^[6]
• HES6^[7]
• RUNX3^[8]
• SIX3^[9]
• RUNX1^[8]

Referencias

1. ↑ Miyasaka H, Choudhury BK, Hou EW, Li SS (Oct 1993). «Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein». Eur J Biochem 216 (1):  pp. 343–52. PMID 8365415. 
2. ↑ Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Oct 1996). «Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia». Genomics 31 (1):  pp. 58–64. doi:10.1006/geno.1996.0009. PMID 8808280. 
3. ↑ «Entrez Gene: TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)».
4. ↑ Grbavec, D; Lo R, Liu Y, Stifani S (Dec. 1998). «Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development». Eur. J. Biochem. (GERMANY) 258 (2):  pp. 339–49. ISSN 0014-2956. PMID 9874198. 
5. ↑ Liu, Fei; Liu Yin, Li Demin, Zhu Yong, Ouyang Weiming, Xie Xin, Jin Boquan (Mar. 2002). «The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain». Mol. Cell. Biochem. (Netherlands) 232 (1-2):  pp. 163–7. ISSN 0300-8177. PMID 12030375. 
6. ↑ Grbavec, D; Lo R, Liu Y, Greenfield A, Stifani S (Jan. 1999). «Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms». Biochem. J. (ENGLAND) 337 ( Pt 1):  pp. 13–7. ISSN 0264-6021. PMID 9854018. 
7. ↑ Gao, X; Chandra T, Gratton M O, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep. 2001). «HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program». J. Cell Biol. (United States) 154 (6):  pp. 1161–71. doi:10.1083/jcb.200104058. ISSN 0021-9525. PMID 11551980. 
8. ↑ ^{a b} Levanon, D; Goldstein R E, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y (Sep. 1998). «Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (20):  pp. 11590–5. ISSN 0027-8424. PMID 9751710. 
9. ↑ López-Ríos, Javier; Tessmar Kristin, Loosli Felix, Wittbrodt Joachim, Bovolenta Paola (Jan. 2003). «Six3 and Six6 activity is modulated by members of the groucho family». Development (England) 130 (1):  pp. 185–95. ISSN 0950-1991. PMID 12441302. 

Enlaces externos

• MeSH TLE1+protein,+human